Identification of specific and semi-specific SIRT inhibitors through computer-aided studies
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چکیده
منابع مشابه
Identification of specific and semi-specific SIRT inhibitors through computer-aided studies
+-dependent lysine deacetylases (sirtuins, SIRT1-7) have emerged as potential therapeutic targets for treatment of human illnesses such as cancer, metabolic, cardiovascular and neurodegenerative diseases. Sirtuins possess deacetylase and/or mono-ADP-ribosyltransferase activity, and this activity is directed to histone as well as non-histone targets involved in transcription, metabolism, and ene...
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ژورنال
عنوان ژورنال: Aging
سال: 2011
ISSN: 1945-4589
DOI: 10.18632/aging.100387